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KMID : 0361519930040020081
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Korean Journal of Psychopharmacology
1993 Volume.4 No. 2 p.81 ~ p.89
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Depression and Serotonin
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백인호.
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Abstract
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From a neurobiochemical aspect, the pathophysiology of depression stems from the studies of Schildkraut (1965), and Bunney and Davis (1965) who proposed the so-called "catecholamine hypothesis", and depression might be linked to the CNS serotonin
abnormality. Recently. much attention has been paid to the relationship of deprssion to serotonin.
The theories that abnormality in the CNS serotonin system could be the major pathogenesis are based on the clinical evaluation of antidepressant's effect which is known to block reuptake of the 5-HT and/or to potentiate 5-HT from inhibiting MAO
at
nerve
endings. Also. the deficiency of 5-HT and its metabolite found among patients with depression strongly support these theories. The discovery that in the CNS. the 5-HT neuron are widely distributed which regulate sleep and appetite. and its
destruction
causes depression would also suggest that 5-HT plays a major role in pathogeness of depression
In this brief review. the author discussed the major findings that primarily deais with 5-HT uptake. transport, 5-HT receptor characteristics. and their relationship to depression.
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KEYWORD
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